Introducing new Organic Skin Care Products at Skin Perfection!

Posted on February 22, 2011 by Skin Perfection

 

natural and organic products

NEW! Organic Products

We are pleased to introduce two new products at Skin Perfection. Our New Organic Cleanser and Our Minty Green Toner. Our Organic Skincare Line is loaded with Organic Ingredients.

Cleanse your skin, gently and organically! Our Organic Cleanser contains 93% organic ingredients! Purely organic ingredients nourish without drying, leaving your skin silky soft. Our Essential Organic Cleanser uses natural emulsifyers that are a great alternative to emulsifying wax! Cetearyl Olivate, Sorbitan Olivate, Cetyl Palmitate and Palm Stearic Acid are made from vegetables, they are BSE and solvent free! The Essential Organic Cleanser is a great make-up remover!

Ingredients: Organic Aloe, Organic Coconut, Organic Green Tea, Cetearyl Olivate, Sorbitan Palmitate, Organic Olive Oil, Xanthan Gum, Palm Stearic Acid.

Our Minty Green Organic Toner is made with 97% organic ingreints. Our Minty Green Toner deep cleans pores without chemicals or fillers. The Organic Extracts are Certified Organic, they blend together to clean congested skin without preservatives.

Ingredients: Organic Aloe, Organic Peppermint, Glycerin, Organic Black Willowbark, Organic Bilberry, Organic Sugar Cane, Organic Sugar Maple, Organic Orange, Organic Lemon, Organic Cranberry.

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Beauty Routines, A Quick Guide

Posted on January 10, 2011 by Skin Perfection
Organic-Skincare-Beauty-Routine

Beauty Routines

Now that it is 2011, it’s time to review your beauty routine.  We get so much questions from customers wanting to know what products they should use and when to use them. Here is our quick guide to choosing the right products for a skincare routine that meets your needs.

For women and men in their 20’s, this is the time for basics. Cleanse, Tone, Moisturize and Exfoliate once a week. In your late 20’s, it’s time to start an eye cream.  Hydrated skin will prevent and delay wrinkles from forming. Exfoliating will keep skin fresh.

In your 30’s and 40’s, your skincare routine should look like this: Cleanse, Tone, Serum, Eye Cream, a Hydrator or a Moisturizer, Exfoliate at least once a week. This is the time were sun damaged skin starts to appear. Use a serum on sun damaged areas, lines and wrinkles. This is also the time that Adult Acne can arise. If you battle adult acne, use a hydrator instead of a moisturizer.  Exfoliating remove dull, flaky skin and can help slow down aging.

For Mature skin, men and women over 50, you want to Cleanse, Tone, Serum, Eye Cream, Hydrator, Moisturizer and Exfoliate once a week.  As we age, skin tends to get dryer. Adding a hydrator or Argan oil before your moisturizer will increase moisture and keep your skin supple and plump.

Cleansing: Cleans the skin, removing dirt and debris. Morning and Night, apply a small amount cleanser in your fingertips, massage in an upward circular motion. Rinse well.

Exfoliating: At least once a week, use an exfoliator.  Removing dead skin cells helps promotes cell turnover, removes fine lines and wrinkles and reveals fresh, healthy looking skin!

Toner: Using a toner prepares your skin for serums, it also cleans the pores deep down. Twice daily, Saturate cotton with toner and gently swipe over face and neck. Repeat until cotton comes out completely clean.

Anti Wrinkle Serums: Help repair damaged areas and areas with fine lines and wrinkles. On toner damp skin . Press and pat a small amount of serum on toner damp skin. Use on fine lines and wrinkles. Let dry completely before applying any other spot treatment or moisturizer. If running low on time, take a hair dryer on cool and dry the skin for 30 seconds.

Eye Creams: Lift and firm the eye area, also help with crow’s feet. Use twice daily. Pat gently around eyes. Around and out of upper eye lid and down below eye.

Hydrators: Hyaluronic Acid plumps the skin with a boost of moisture. Apply a small amount to the face and neck.

Moisturizers: For essential hydration. Use a small amount on the face and neck, morning and night. If you are acne prone, use a hydrator instead. If you have combination skin, use a moisturizer on dry areas avoid the T-zone. For those with mature skin, use argan oil before your moisturizer.

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Reveal Beautiful Skin for the New Year with Pretika, Sonic Microdermabrasion Facial Brush!

Posted on January 5, 2011 by Skin Perfection

At Skin Perfection, we are excited to introduce the Pretika, sonic microdermabrasion facial brush!

Finally, an affordable handheld facial brush! We all love the idea of cleansing and exfoliating at the same time. Give your skin a deep clean while removing dirt and debris. The pulsating head removes the outer layer of dry flaky skin cells that can build up and cause fine lines and wrinkles. Your skin will be softer and smoother, reducing the appearance of fine lines and wrinkles, pores will look smaller, who doesn’t love that?! When you are short on time, use it in the shower. The Pretika Sonic Dermabrasion Facial Brush is designed for delicate, sensitive and normal, dry or oily skin types. Compare to Clarisonic! You will love the results without the $200 price tag!

Sonic Microdermabrasion for Smooth Skin

Pretika: Sonic Dermabrasion

Pretika Professional Powered using Micro-Pulsating Vibration Cleansing Technology

  • Battery Overcharge Protection Feature, rechargeable Ni-MH battery technology (more energy output than Ni-Cad and shorter charging time) – the perfect combination for the professional or consumer
  • Use separately or in combination with skin care treatments used by the professional or consumer
  • Built-In Timer – signals at 20-second intervals to encourage a more complete cleansing
  • Advanced Brush Head Technology – replaceable micro-fiber brush heads for delicate, sensitive and normal skin types – designed to get deep into the pores and wrinkle lines
  • Prepares the skin to better absorb skin care treatments – which increases the performance of the topical skin care treatments
  • Water Resistant
  • Cordless

Hurry and get yours soon (At an exceptional special price!)! Visit http://www.skin-perfection.com/store/cleansers/pretika-sonic-dermabrasion-facial-brush/!

At Skin Perfection, we are excited to introduce the Pretika, sonic microdermabrasion facial brush! Finally, an affordable handheld facial brush! We all love the idea of cleansing and exfoliating at the same time. Give your skin a deep clean while removing dirt and debris. The pulsating head removes the outer layer of dry flaky skin cells that can build up and cause fine lines and wrinkles. Your skin will be softer and smoother, reducing the appearance of fine lines and wrinkles, pores will look smaller, who doesn’t love that?! When you are short on time, use it in the shower. The Pretika Sonic Dermabrasion Facial Brush is designed for delicate, sensitive and normal, dry or oily skin types. Compare to Clarisonic! You will love the results without the $200 price tag!

Pretika Professional Powered using Micro-Pulsating Vibration Cleansing Technology comes with a Battery Overcharge Protection Feature, rechargeable Ni-MH battery technology (more energy output than Ni-Cad and shorter charging time) – the perfect combination for the professional or consumer. Use separately or in combination with skin care treatments used by the professional or consumer. There is a Built-In Timer – signals at 20-second intervals to encourage a more complete cleansing. Advanced Brush Head Technology – replaceable micro-fiber brush heads for delicate, sensitive and normal skin types – designed to get deep into the pores and wrinkle lines. Prepares the skin to better absorb skin care treatments – which increases the performance of the topical skin care treatments. Pretika is Water Resistant and Cordless.

Hurry and get yours soon (At an exceptional special price!)! Visit http://www.skin-perfection.com/store/store.php/products/pretika-sonic-dermabrasion-facial-brush-exfoliate-and-cleanse!

Posted in Acne, Anti Aging, Combination Skin, Dry Skin, Mature Skin, New Products, Oily Skin, Sensitive Skin, Skin Conditions, Sun Damaged Skin | Tagged , , , , , , , , , | Leave a comment

The 5 Best Anti Aging Ingredients of 2010 & The 5 Best Organic Anti Aging Ingredients for great skin care products!

Posted on December 20, 2010 by Skin Perfection
best-anti-aging-ingredient

syn-ake

The 5 Best Anti Aging Ingredients of 2010!
Here is our list of the best anti aging ingredients this year!

1. SNAP 8:
Snap 8 is an elongation of our favorite hexapeptide, Argireline. It is anti-aging octapeptide that works to eliminate wrinkles by relaxing expression lines. Snap 8 can reduce the depth of wrinkles by 63%! Clinical studies have shown that using Snap 8, twice a day, for 28 days with a 10% solution can reduce wrinkle depth up to 63%. That is phenomenal!

2. SYN AKE:
Syn Ake is an anti wrinkle compound based on snake venom (Waglerin-1) peptide that is found in the Venom of the Temple Viper. that has been shown to mimic the effects of Botox without injections! In a clinical trial using 45 subjects using the product twice a day for 28 days, one-third used Syn Ake, one-third Acetyl Hexapeptide-8 (Argireline) and one-third a placebo, the results were based on two areas: skin roughness and wrinkle depth. The average smoothing for each group of fifteen subjects was 21% for Syn Ake and 4% for Argireline. The average reduction in wrinkle depth was 20% for Syn Ake and 2% for Argireline! Syn Ake has also been shown to reduce wrinkle size up to 50%.

3. RENOVAGE aka TEPRENONE:
Teprenone, also known as Renovage, is part of a Nobel Prize winning discovery called TELOMERES, which basically keep cells from dying and therefore keep skin looking younger for much longer. Renovage expands a cells lifetime by targeting the cell components that ensure lifespan and actively limits oxidative build up in your skin cells. Teprenone improves skin moisture, redness, pore size, skin roughness and fine lines in 75 to 100% of the test persons!

4. SPIN TRAP:
Spin Trap: the smart antioxidant that traps free radicals and then converts the free radicals into oxygen that the body can reuse it for tissue respiration.

5. MATRIXYL 3000:
Matrixyl 3000, or Palmitoyl Oligopeptide and Palmitoyl Tetrapeptide 7, has long been a favorite! The simple reason is that it works and people love the results! Matrixyl uses 2 matrikines to synergistically send messengers to reconstruct damaged collagen. Matrixyl diminishes wrinkles by 45%, It lifts and firms the skin and restores a youthful appearance.

HONARABLE MENTION!
APPLE STEM CELL:
Phytocell Tec Malus Domestica, or Swiss Apple Stem Cell extract, delays aging. It is a revolutionary anti aging extract that rejuvenates aging skin. It protects our own human stem cells and promotes longevity. PhytoCell uses a rare Swiss apple that protects our skin cells against oxidative stress and it repairs damaged DNA. PhytoCell Tec contains phospholipids that deliver apple stem cell deep into the skins matrix, allowing skin cells to self renew. Studies have shown that 2% of Phytocell Tec decreased the wrinkle depth of crow’s feet by 8% in just 2 weeks! And 15% in just 4 weeks! Phytocell won the BSB Innovation Prize for the best active ingredient.

organic anti aging ingredients

Organic Anti Aging Ingredients

The 5 Best Anti Aging Organic Ingredients:
Here is our list of the vest organic ingredients or extracts in our skincare.

1. SILK AMINO ACIDS:
Silk Amino acids are the building blocks of protein. They help build collagen below the epidermis, keeping our skin plump and full. Amino Acids restore elasticity, keeping your skin healthy and strong! Amino Acids are Sodium L-Pyrrolidone Carboxylate, Sodium Lactate, L’Arginine, L-Aspartic Acid, L-Pyrrolidonecarboxylic Acid, Glycine, L-Alanine, L-Serine, L-Valine, L-Proline, L-threonine, L-Isoleucine, L-Histidine, L-Phenylalanine.

2. ALGAE:
There are many types of Algae; Blue Green Algae from Klamath Falls, Oregon contains chlorophyll, protein, minerals, amino acids and enzymes to help restore moisture and improve the skin’s elasticity.

3. MARINE COLLAGEN:
Marine Collagen is the most similar to human collagen. With its polysaccharides, vitamins and essential sea minerals, it aids in the healing and structuring of connective tissue. It plumps the skin, reduces fine lines and wrinkles, improves skin elasticity, and produces firmer, more even toned skin.

4. PINE BARK:
Also called French Maritime Pine Bark or Pycnogenol. Pine Bark keeps the skin firm and prevents wrinkles. It inhibits the breakdown of collagen and elastin. This super antioxidant helps improve the skins circulation allowing for better absorption of oxygen and nutrients. Pine Bark gives the skin a vibrant healthy glow!

5.COPPER PEPTIDES:
Copper has the ability to aid in tissue regeneration. Copper peptides boost the body’s healing abilities that rebuild and renew skin.

Our Organic Anti Aging Skincare with the latest anti aging ingredients, organic extracts and antioxidant will erase wrinkles, firm and tighten skin, build collagen and improve your skin’s tone and texture without harsh chemicals or parabens! www.skin-perfection.com!
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Skin Perfection Organic Anti Aging Peptide Packed Serums!

Posted on November 7, 2010 by Skin Perfection

Our advanced Organic Anti Aging Serums are the ultimate in increasing skins firmness, elasticity, and smoothness. They contain powerful peptides that repair our skins tone and texture. Our nourishing blend of organic and natural extracts and anti aging actives produce a potent, rejuvenating blend to keep your skin soft and supple. As our skin ages, we loose the components found in younger skins. Specific ingredients allow us to regenerate those components and slow the signs of aging.

Organic Anti Aging Serums with Peptides

Peptides! Peptides! Peptides!

Peptides! Peptides! Peptides!

Our serums are loaded with them because they work! Peptides are the gateway to wrinkle free skin! At, Skin Perfection we use the most advanced anti aging peptides. Peptides help to regulate skin cell function. They send chemical messengers to stimulate and maximize collagen production. When our skin produces more collagen we naturally begin to look younger. The skin becomes smoother, fuller, and more plump. Peptides smooth out the skin resulting in a reduction of fine lines and wrinkles. Peptides increase the firmness of the skin (the sagging jowls) resulting in tighter, younger looking skin. One of the best reasons why we love peptides so much is because they are non irritating and penetrate the skin without redness. So that is great news for those who may suffer from Rosacea or Sensitive skin.

Anti Wrinkle Peptides:

Argireline, Snap 8 and Syn Ake work their magic on our aging skins. They erase our wrinkles, using neurotransmitters to stop muscle contractions that cause wrinkles.

Argireline: Also known as Acetyl Hexapeptide 8.  Argireline is clinically proven to reduce the size and depth of wrinkles. Argireline uses the SNARE Complex to stop the muscle contractions giving the “BOTOX” effect which prevents wrinkles from forming.

Snap 8 is an elongation of our favorite hexapeptide, Argireline. It is anti-aging octapeptide that works to eliminate wrinkles by relaxing expression lines. Snap 8 can reduce the depth of wrinkles by 63%! Clinical studies have shown that using Snap 8, twice a day, for 28 days with a 10% solution can reduce wrinkle depth up to 63%. That is phenominal!

Syn Ake is an anti wrinkle compound based on snake venom (Waglerin-1) peptide that is found in the Venom of the Temple Viper. that has been shown to mimic the effects of Botox without injections! In a clinical trial using 45 subjects using the product twice a day for 28 days. One-third used Syn Ake, one-third Acetyl Hexapeptide-8 (Argireline) and one-third a placebo. The results were based on two areas: skin roughness and wrinkle depth.

The average smoothing for each group of fifteen subjects was 21% for syn ake and just 4% for Argireline. The average reduction in wrinkle depth was 20% for Syn Ake and 2% for Argireline! Syn Ake has also been shown to reduce wrinkle size up to 50%. Syn Ake has a cumulative effect, for full effect to take place use it should be used for 30 days. Syn Ake won the Swiss Technology Award.

Collagen Building Peptides:

Matrixyl 3000, or Palmitoyl Oligopeptide and Palmitoyl Tetrapeptide 7. Matrixyl uses 2 matrikines to synergisticly send messengers to reconstruct damaged collagen.

* Matrixyl diminishes wrinkles by 45%
* Lifts and firms the skin
* Restores skins youthful appearance

Matrixyl is a lipopeptide that stimulates the matrix molecules in the skin, particularly collagen and fibronectin. Simply, it sends a chemical message to the cells to make new collagen.( Collagen is a protein – through the natural processes of aging, collagen in the skin is lost resulting in wrinkles) Matrixyl is a fatty acid mixed with amino acids. The active ingredient in Matrixyl is called Micro-collagen which is a peptide. When applied to the skin, matrixyl penetrates the deeper layers of the skin. Matrixyl with Micro-collagen contributes to the characteristics of a younger, smoother, less wrinkled skin.
Syn Coll is Palmitoyl Tripeptide-5, a peptide that has been shown to stimulate the body’s ability to create collagen and thereby eliminate the appearance of wrinkles.

Hydrators:

One of the most common problems with skin is that it is dehydrated. Dehydration can cause wrinkles! Those with oily skin shy away from moisturizers because they don’t want to break out. Hydrators are the best way to give moisture to the skin without causing breakouts! Our favorite hydrator is Hyaluronic Acid. It is “Nature’s Moisture” and can hold up to 1,000 times it’s own weight. That is why it PLUMPS out your skin!

Hyaluronic Acid:

Is a polysaccharide that hydrates the skin. It raises the skin’s moisture level and plumps up the skin promoting youthful healthy skin that is supple!

Free Radical Scavengers:

We are bombarded everyday with free radicals from air pollution. Free Radicals wreak havoc on our skin causing premature aging. Free Radical scavengers protect our skin from the damage and the new “super scavengers” now reuse the trapped free radicals!

Spin Trap: the smart antioxidant that traps free radicals and then converts the free radicals into oxygen that the body can reuse.

Organic Ingredients:

At Skin Perfection, we believe that great skincare nourishes the skin. We do not use harsh chemicals or fillers in our skincare. We do use a myriad of natural ingredients and organic extracts. For optimal skin nutrition, organic extracts provide the skin with the vitamins and minerals they need to moisturize and heal the skin.

Natural and Organic Extracts:

Pepha Tight is algae and pullalan. Pepha Tight contains marine collagen. Marine Collagen is the most similar to human collagen. With it’s polysaccharides, vitamins and sea minerals, it aids in the healing and structuring of connective tissue. Pepha Tight plumps the skin, reduces fine lines and wrinkles, improves skin elasticity and gives and instant tightening effect.

Phytocell Tec Malus Domestica:

or Swiss Apple Stem Cell extract, delays aging. It is a revolutionary anti aging extract that rejuvenates aging skin. Apple Stem Cells protect our own human stem cells and promote longevity. PhytoCell uses a rare swiss apple that protects our skin cells against oxidative stress and it repairs damaged DNA. PhytoCell Tec contains phospholipids that deliver apple stem cell deep into the skins matrix, allowing skin cells to self renew. Studies have shown that 2% of Phytocell Tec decreased the wrinkle depth of crow’s feet by 8% in just 2 weeks! And 15% in just 4 weeks!

Teprenone, also known as Renovage, is a plant extact that is part of a Nobel Prize winning discovery called TELOMERES, which basically keep cells from dying and therefore keep skin looking younger for much longer. targets the cell components that ensure lifespan and actively limits oxidative build up in your skin cells. Teprenone improves skin moisture, redness, pore size, skin roughness and fine lines in 75 to 100% of the test persons!

Our new Expression Line Deep Wrinkle Serum combines the hydration of Hyaluronic acid and the wrinkle fighting properties of a serum. It is a potent blend that defends the formation of new wrinkles while repairing and rebuilding the skin’s matrix. Syn Coll and Matrixyl are anti aging actives that increases our body’s ability to create new collagen. It is with these actives that the collagen in our face becomes replenished and that youthful, plump skin appears. Argireline and Snap 8 are peptides designed to relax the muscles that cause wrinkles. Syn Ake goes a step further to stop deeper wrinkles.

Posted in Acne, Anti Aging, Antioxidants, Articles, Ingredients, Mature Skin, Natural Products, New Products, Normal Skin, Oily Skin, Organics, Rosacea, Sensitive Skin, Sun Damaged Skin | Tagged , , , , , , , , , , , , , , , , , , , | Leave a comment

New! Natural Emulsifing System, an Ecocert alternative to Emulsifying Wax

Posted on November 4, 2010 by Skin Perfection

At Skin Perfection, we are always ways to offer you the most natural and organic skin friendly products! The latest: a Natural Emulsifying System. You will love our new products as an alternative to Emulsifying Wax without having to morgage the house to pay for skincare.

Natural Emulsifying System

The Natural Emulsifying System is made of Cetearyl Olivate, Sorbitan Olivate, Cetyl Palmitate and Palm Stearic Acid. The Natural Emusifying System is of vegetable origin and certified BSE-free and solvent free.

Our new system can be found in our A Retinol Night Repair, Hand and Body Lotion and our Ultimate Night Moisturizer.

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What is Radish Root Ferment?

Posted on November 4, 2010 by Skin Perfection
Leucidal Liquid aka Radish Root Ferment

Radish Root, a natural alternative to synthetic preservatives and parabens.

Radish Root Ferment Filtrate is Leucidal® Liquid, it is ECOCert Approved for use in Certified Organic products. Leucidal is a natural preservative derived from radishes fermented with Leuconostoc kimchii, a lactic acid bacteria that consists of a peptide with antimicrobial benefits. Leucidal liquid is a wonderful alternative to traditional synthetic preservatives such as parabens.

Leucidal is a natural alternative to synthetic preservatives.  It may also be useful as a topical antimicrobial when addressing problem skin or scalp conditions.  In clinical studies, it has shown to successfully inhibit microbial growth such as with S. aureus, E. coli, P. aeruginosa, C. albicans, A. niger, K. pneumoniae, B. cepacia.

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Spin Trap, What is it and why do we love it?

Posted on November 4, 2010 by Skin Perfection
Spin Trap, PHENYL BUTYL NITRONE, NITRONE, PBN, the smart antioxidant that traps free radicals and then converts the free radicals into oxygen that the body can reuse it for tissue respiration.  

 PBN is the most extensively researched and widely used Spin Trap

Spin Trap Super Antioxidant

The most commonly used spin trap and the standard which measures new ones is PBN – alpha phenyl-N-tert butyl nitrone. Hundreds of studies have been conducted over the last ten years that have tested PBN and other “spin traps” in numerous conditions.4 Spin traps have been shown to affect cellular oxidation states and oxidatively sensitive enzyme systems.5

  • PBN has been shown to be an excellent neuroprotective and anti-inflammatory agent.6
  • PBN has extended the life span of mice,7 improved cognitive performance in rats,8 reversed protein oxidation in aged gerbils and returned them to youthful states.9
  • PBN has attenuated hydroxyl radical formation in ischemia-reperfusion injury,10 blocked nitric oxide synthase, which minimized the exitotoxicity of peroxynitrite radical.11 Paradoxically, PBN acted as a delivery system for transporting beneficial nitric oxide to targeted areas undergoing oxidative stress.12

Low toxicity

PBN has been shown to be of extremely low toxicity even at the highest dosages and with long-term use.13a,13b The effective dosage of PBN in humans for treating age and ischemic related disorders is expected to be between approximately 1 and 10 mg/70 kg body weight. This equates to 70-700mg for a 70 kg man. Toxicity tests have demonstrated that PBN is completely innocuous, with such low toxicity that it was not possible to determine an LD.sub.50.13c

Spin Traps work differently than antioxidants

Recently, researchers found that the underlying mechanism of “spin trap” activity differs from antioxidants. Spin traps suppress gene transcriptional factors associated with a variety of pathophysiological states.14 In particular, spin traps modulate NF kappa-B regulated cytokines and inducible nitric oxide synthase that are implicated in AIDS, arthritis, arteriosclerosis, Alzheimer’s disease and other pro-inflammatory disease conditions.15 Arguably, this mechanism involves actions at a level proximal to oxidatively sensitive signal amplification systems rather than simple neutralization of free radicals.16

PBN has a wide range of practical applications

Because PBN alters several fundamental cellular processes and metabolic pathways, it may be efficacious for a wide range of conditions. Between the years of 1991 and 2000, researchers, John Carney at University of Kentucky Research Foundation and Robert Floyd at Oklahoma Medical Research Foundation, filed a series of U.S. patents for methods of using PBN. They recommended PBN for many diverse conditions that involve oxidative stress and free-radical pathology.16-23

Aging

Aging has been demonstrated to be associated with the production of abnormally high levels of oxidized proteins. The consequence of this increased level of protein oxidation is an abnormally low level of critical enzymes in the affected cells. Most, if not all, cells in the body will undergo abnormally high levels of protein oxidation and there will be decreases in antioxidant systems and abnormally low levels of mitochondrial function. The protein oxidation is thought to arise from oxygen free radicals, largely generated via a metal catalyzed reaction within the cell. Studies have now been conducted that daily administration of a free radical spin trapping compound, PBN, for fourteen days completely reverses this process. Not only is the level of protein oxidation decreased, but the abnormally low level of enzyme activity is restored to normal.

Dr. Denham Harman, the father of the Free Radical Theory of Aging, and keynote speaker at the 2nd Annual Anti-aging Conference in Monaco, referred to PBN and spin traps as a ‘breakthrough in anti-aging therapy’ with the potential to significantly slow down the aging process.

PBN Cosmetic Applications

The Standard Nitrone Spin Trap for Cosmetic Applications

Profile

PBN (N-tert-butyl-alpha-phenylnitrone) is the established nitrone “spin trap”. The term “spin trap” is derived from the technique used to detect and identify free radicals, electron spin resonance. Reactive free radicals are attracted and bound to the beta carbon atom in the spin trap, forming a spin adduct and effectively “trapping” the free radical, allowing the structure of the trapped radical to be deduced.

Spin traps are exceptional molecules that can trap and detoxify damaging free radicals which age the skin. PBN blocks and detoxifies harmful free radical molecules from damaging cells and reduces overall systemic inflammation – the culprit recently discovered to underlie all the degenerative diseases of aging.

PBN has been shown to be an excellent neuroprotective and anti-inflammatory agent and transforms skin damaging free radicals into productive regenerative activity.

Cosmetic Applications and Benefits of PBN Powder

  • PBN can provide unique protection against free radical induced skin damage.
  • PBN can be administered topically to control inflammatory processes; an underlying cause of skin aging.
  • PBN is useful for enhancing the activities of topically applied antioxidants such vitamin C, vitamin E and Lipoic Acid and is commonly incorporated into preparations which include other antioxidants.
  • Spin Traps show promise as blocking agents for inflammation caused by UV exposure. Unlike traditional sunscreens, which prevent UV mediated inflammation when used before exposure, spin trap compounds scavenge free radicals and minimize the inflammatory response during and for up to 12 hours after exposure to UV light. By interfering with the inflammatory cascade, these compounds may prevent collagen and elastin degradation, and thus premature aging of the skin.

Specifications

PBN powder for cosmetic application is doubly recrystalised from high purity solvents and is greater than 98% pure (HPLC). PBN is a white crystalline solid; melting point 73°-74° C. PBN powder is poorly soluble in water, but soluble in alcohols. PBN powder is hydrolyzed at low pH into benzaldehyde and N-tert-butyl-hydroxylamine.

Dr. Denham Harman, the father of the “Free Radical Theory of Aging”, and keynote speaker at the 2nd Annual Anti-aging Conference in Monaco, referred to PBN and spin traps as a “breakthrough in anti-aging therapy with the potential to significantly slow down the aging process.”

In his bestselling book, The Wrinkle Cure, Dr. Nicholas Perricone notes that spin traps are capable of “Stopping Free-Radical Damage Before it Begins…” and that such agents ‘create a barrier – a trap – that holds free radicals in place’ so that they can be “stopped before they scar the cells that make up your skin.” He also claims that researchers “found that the traps actually prevented the free radicals from moving from place to place and damaging cells… and that ‘the odds are these free-radical fighters will become a highly effective method of maintaining a youthful, radiant complexion throughout life… Thanks to a spin trap, we will make quantum leaps in the effort to control the effects of aging…”

References

  1. Nitrone inhibition of age associated oxidative damage. Floyd, R.A. Ann NY Acad Sci 2000; 899:222-37
  2. a) Nitrones, their value as therapeutics and probes to understand aging. Floyd RA, Hensley K, et al. Mech Ageing Dev. 2002 Apr30;123(8):1021-31.
    b) Do Spin Traps also act as classical chain-breaking antioxidants? A quantitative kinetic study of PBN in solution and in liposomes. Free Rad Biol Med 2000 Apr 1; 28 (7) 1079-90
  3. a) Synthesis and antioxidant efficiency of a new amphiphilic spin-trap derived from PBN and Lipoic Acid. Durand G, Polidori A, Salles JP, Prost M, Durand P, Pucci B. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2673-6.
    b) Unique in vivo applications of spin traps , Berliner, L.J. et. al. Free Rad Biol Med 2001 Mar 1; 30 (5) :489-99
  4. Pharmacokinetics and metabolism of the reactive oxygen scavenger alpha-phenyl-N-tert-butylnitrone in the male Sprague-Dawley rat. Trudeau-Lame ME, Kalgutkar AS, LaFontaine M. Drug Metab Dispos. 2003 Feb;31(2):147-52.
  5. Nitrone-based free radical traps as neuroprotective agents in cerebral ischaemia and other pathologies. Hensley, K. Int Rev Neurobiol 1997; 40: 299-317
  6. a) Antioxidants, oxidative stress, and degenerative neurological disorders. Floyd, R.A., Proc Soc Exp Biol Med 1999 Dec; 222 (3) : 236-45
    b) Inhibition of NF-kappaB, iNOS mRNA, COX2 mRNA, and COX catalytic activity by PBN. Kotake, Y., Biochim Biophys Acta 1998 Nov 19; 1448 (1): 77-84
  7. A spin trap, PBN extends the life span of mice. Saito, K; Biosci Biotech Biochem 1998 Apr; 62 (4): 792-4
  8. Antioxidant treatment with PBN improves the cognitive performance and survival of aging rats. Sack, C.A.; Neurosci Lett 1996 Mar 1; 205 (3): 181-4
  9. Effect of the spin trapping compound PBN on protein oxidation and life span. Dubey, A., Arch Biochem Biophys 1995 Dec 20: 324 (2): 249-54

10.  PBN attenuates hydroxyl radical production during ischemia-reperfusion injury of rat brain: an EPR study. Sen, S., Free Radic Res Commun 1993: 19 (4) 255-65

11.  In vivo or in vitro administration of the nitrone spin-trapping compound, n-tert-butyl-alpha-phenylnitrone, (PBN) reduces age-related deficits in striatal muscarinic receptor sensitivity. Joseph JA, Cao G, Cutler RC.Brain Res. 1995 Feb 6;671(1):73-7.

12.  a) Neuroprotective effects of nitrone radical scavenger S-PBN on reperfusion nerve injury in rats. Gray C, Nukada H , Jackson DM, McMorran PD, Wu A , Ma F. Brain Res. 2003 Aug 29;982(2):179-85.
b) ESR characterization of a novel spin-trapping agent, 15N-labeled N-tert-butyl-alpha-phenylnitrone, as a nitric oxide donor. Saito K, Yoshioka, H. Biosci Biotechnol Biochem . 2002 Oct;66(10):2189-93.
c) Differences in cerebral reperfusion and oxidative injury after cardiac arrest in pigs. Liu XL, Wiklund L, Nozari A, Rubertsson S, Basu S. Acta Anaesthesiol Scand. 2003 Sep;47(8):958-67.

13.  a) In vitro and in vivo assessment of the irritation potential of different spin traps in human skin. Fuchs J, Groth N , Herrling T. Toxicology. 2000 Oct 26;151(1-3):55-63.
b) Cutaneous tolerance to nitroxide free radicals and nitrone spin traps in the guinea pig. Fuchs J, Groth N , Herrling T. Toxicology. 1998 Feb 20;126(1):33-40.
c) Carney, J, et al. US Patent Application 20050272724, December 8, 2005.

14.  Increased oxidative stress brought on by pro-inflammatory cytokines in neuro- Degenerative processes and the protective role of nitrone based free radical traps. Floyd R.A.; Life Sci 1999; 65 (18-19): 1893-9
a) Expression of cytokines and activation of transcription factors in lipopolysaccharide-administered rats and their inhibition by PBN. Sang, H., Arch Biochem Biophys 1999 Mar 15; 363 (2): 341-8

15.  Spin trap salvage from endotoxemia: the role of cytokine down-regulation. Surgery. 1992 Aug;112(2):130-9; discussion 138-9. Pogrebniak HW, Merino MJ, Hahn SM, Mitchell JB, Pass HI.

16.  Carney J, et al. United States Patent, 5,578,617 November 26, 1996

17.  Carney J, et al. United States Patent, 6,107,315. August 22, 2000

18.  Carney J, et al. United States Patent, 5,405,874. April 11, 1995

19.  Carney J, et al. United States Patent, 5,025,032. June 18, 1991

20.  Carney J, et al. United States Patent, 5,681,965. October 28, 1997

21.  Carney J, et al. United States Patent, 6,002,001. June 18, 1999

22.  Carney J, et al. United States Patent, 5,622,994. April 22, 1997

23.  Carney J, et al. United States Patent, 5,025,032. June 18, 1991

24.  PBN protects against 3,4-methylenedioxymethamphetamine-induced depletion of serotonin in rats. Yeh, S.Y., Synapse 31:169-177 1999

Posted in Anti Aging, Antioxidants, Articles, Chirally Correct, Ingredients | Tagged , , , , , , , , , | Leave a comment

The ANSR: Beam for Youthful looking Clear Skin!

Posted on October 24, 2010 by Skin Perfection

At Skin Perfection, we have scoured the market looking for at home products that work. We have tested many different products and laser light treatments for at home use. Most were small and only covered a small area at a time or they were so expensive. Then we found the Ansr, an easy to use photo light therapy beam and it’s affordable! The Ansr: beam is a light hand held light therapy that works! Our results have been fabulous. It works on Cystic and Adult Acne, clearing up the skin within 2 weeks. Most of us saw improvements right away. The bonus is that it clears up clogged pores and acne and then clears up acne scars. All without the use of chemicals!

After using the blue light you can choose to use the red light for anti aging. The red light increases cell turnover. It tightens up skin and gives a nice lift for the face. It even helps those with redness, especially those with Rosacea who can’t use many skincare products. Use the ANSR twice a day and you too will notice wonderful results! Grab yours today at http://www.skin-perfection.com/store/light-therapy/the-ansr-beam-anti-aging-anti-blemish-at-home-laser/!

The Ansr is a great natural alternative to antibiotics for acne. It also is a great alternative to surgical face lifts! We truly believe that treating the skin at the root of the problem (ie. killing acne causing bacteria or giving energy to cells to speed up life’s natural process) is the way to go! It only takes a few minutes a day, twice a day! It is so easy and you skip the dermatologist which can be very costly and time consuming!

ANSR: Beam Blue and Red Photo Light Therapy

The Ansr: for Clear Skin

The ANSR: Beam
ANSR: BEAM Your acne phototherapy and anti-aging phototherapy solution.The ANSR: BEAM is a whole new approach to restoring a more youthful appearance without surgery or the expense of clinical laser treatments. The secret is a new powerful, proven technology with red and blue light therapy that penetrates deep beneath the skin to treat and rejuvenate. The ANSR: BEAM emits harmless LED high-intensity red and blue light waves.

PRODUCT FEATURES & BENEFITS

• RED and BLUE light in one device

• Rechargeable, Cordless and Compact

• Five minute automatic treatment timer
How Phototherapy Works to Fight Acne

The ANSR: BEAM utilizes safe, non-invasive, clinically proven blue light therapy (430nm) technology—a favorite of dermatologists worldwide. The BEAM kills acne causing bacteria and stimulates collagen deep below the skin’s surface to control acne breakouts and improve overall skin texture and tone.

The ANSR: Clears up Adult Ance and Cystic Acne

The ANSR: Clears up Adult Ance and Cystic Acne
How Phototherapy Works to Fight Aging

The Ansr: Tightens and Firms for Youthful Looking Skin

The Ansr: Tightens and Firms for Youthful Looking Skin

The BEAM’s red light wavelengths (632nm) penetrate the skin deeply to stimulate collagens to grow new, healthier cells quickly. These new cells rejuvenate the skin, improving skin tone, reducing redness and filling in fine lines for a radiant, smooth complexion.

Get the ANSR: today and receive free shipping ONLY at http://www.skin-perfection.com!
Posted in Acne, Anti Aging, Articles, Combination Skin, DIY Cosmetics, Dry Skin, Mature Skin, Natural Products, New Products, Normal Skin, Oily Skin, Organics, Rosacea, Sensitive Skin, Skin Conditions, Sun Damaged Skin | Tagged , , , , , , , , , , , , , , , , | Leave a comment

New Chirally Correct Cleansers!

Posted on October 14, 2010 by Skin Perfection

Youthful Woman, chirally correct skincareWe love suggestions from our customers! Many of you have asked for more Chirally Correct products. We listened! At Skin Perfection, we are introducing more Chirally Correct Cleansers this week! We now carry 3 Chirally Correct Cleansers, Brightening, Sensitive and AHA! Oh, did we mention they are affordable too!

Our Sensitive Skin Cleanser is our gentlest cleanser, specially formulated for those who are sensitive to cosmetic ingredients and fragrance. Our Sensitive Skin Cleanser is a light, non scented gel.  Our Sensitive Skin Cleanser contains Nymphaea Coerulea (Blue Lotus) Flower Extract which promotes micro circulation and calms the skin.  Shea Butter moisturizes and Zeolite to help remove toxins from the environment and clean out impurities for clean skin.

Our Alpha Hydroxy Cleanser gently exfoliates and removes the dead skin cells while cleansing to reveal smoother skin. Our Alpha Hydroxy Cleanser is a fruity, light gel with Salicylic and Lactic acids. Mangosteen and Raspberry extracts help with problematic skin, they calm and regulate skin with their anti-bacterial, anti-fungal and anti-inflammatory properties.  Our AHA Cleanser is great for normal to oily skin types, especially those who are acne prone. The Alpha Hydroxy Acids are a combination of Salicylic Acid and Lactic acid which are natural fruit acids. They help stimulate new cell growth, refining fine lines and wrinkles, and prevents pores from clogging. Yogurt extract nourishes the skin with probiotics, proteins and vitamins; fibroblast growth factor stimulates new cell growth. Mangosteen and Raspberry fruit extracts are packed full of antioxidants that are anti-bacterial and calm the skin.

Posted in Acne, Anti Aging, Antioxidants, Articles, Chirally Correct, Combination Skin, Natural Products, New Products, Normal Skin, Oily Skin, Sensitive Skin, Sun Damaged Skin | Tagged , , , , , , , , , , , , , , , , , , , | Leave a comment